Therapeutic Effects of Herbal Leaves Group (Green Tea & Sage) on Liver Cancer

Abstract

Tea is a beverage consumable next to water worldwide, made from the leaves of theaceae family. Green tea (Camellia Sinensis) tree, grown in China and India, contains good medical properties. Name of salvia in Latin meaning treatment, made from the leaves of labiatae family. Sage (Salvia officinalis) plant, grown in general in mediterranean sea Country. In order to study the therapeutic effects of leaves group, each one alone, on liver cancer, 0.1 ml/100g of aflatoxin B1 (AFB1) was administrated intra- peritoneal in male Wister Albino rats for a period of 10 days to cause liver cancer. Green tea and sage, each one alone, were given to rats for a period of 30 days. The animals were killed at the end of the study and blood was tested for some biochemical parameters including some key enzymes such as aspatate amino transferase (AST), alanine amino transferase (ALT), gammaglutamyl transferase (GGT), and other parameters which include bilirubin, urea, uric acid, creatinine, cholesterol, triacylglycerols, glucose, hemoglobin also part of the liver samples were taken to determine the content of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and total proteins, the other part was used for histological examination. Those analyses were compared to control animals that given AFB1 but not treated. The results from this study demonstrated that green tea prevented the proliferation of liver cancer at the initiating stage by inhibiting AFB1 effects on DNA and regeneration of hepatocyte cells, in sage the effects were lesser than green tea.