Abstract
Focused ultrasound (FUS)-mediated opening of the blood-brain barrier (BBB) has been used to promote drug delivery to the brain. However, in a mouse model of Alzheimer’s disease, FUS has proven to be effective for reducing pathology and improving cognition, even in the absence of exogenous drug application. We have explored single and repeated FUS treatments in mice at both early and late stages of plaque pathology using a transgenic (Tg) mouse model of Alzheimer’s disease.
Highlights
Background/introduction Focused ultrasound (FUS)-mediated opening of the blood-brain barrier (BBB) has been used to promote drug delivery to the brain
In a mouse model of Alzheimer’s disease, FUS has proven to be effective for reducing pathology and improving cognition, even in the absence of exogenous drug application
We have explored single and repeated FUS treatments in mice at both early and late stages of plaque pathology using a transgenic (Tg) mouse model of Alzheimer’s disease
Summary
Background/introduction Focused ultrasound (FUS)-mediated opening of the blood-brain barrier (BBB) has been used to promote drug delivery to the brain. Therapeutic effects of focused ultrasoundmediated blood-brain barrier opening in a mouse model of Alzheimer’s disease Alison Burgess*, Sonam Dubey, Tam Nhan, Isabelle Aubert, Kullervo Hynynen From Current and Future Applications of Focused Ultrasound 2014.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
