Abstract
Purpose: To study the therapeutic influence of meloxicam-glucosamine sulfate combination in patients with osteoarthritis and their effect on serum CTX-I, CTX-II, COMP and MMP-3.
 Methods: A total of 88 patients with osteoarthritis were assigned to control (n = 44) and treatment groups (n = 44), using the random number table method. Control group was given 7.5 mg of meloxicam, while treatment group received 0.5 g of glucosamine sulfate capsule in addition to meloxicam. Both groups were treated continuously for 8 weeks. Serum levels of C-terminal telopeptide of type I collagen (CTX-I), C-terminal telopeptide of type II collagen (CTX-II), cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) were compared for the two groups after treatment.
 Results: Lysholm score significantly increased in the two groups after treatment. Serum CTX-I, CTX-II, COMP and MMP-3 in the two groups were significantly lower than before treatment, but the reductions were more pronounced in the treatment group (p < 0.05). During treatment, mild vomiting and pruritus of the skin appeared in both groups, but these were relieved after symptomatic treatment without any serious adverse reactions.
 Conclusion: Treatment with a combination of meloxicam and glucosamine sulfate produces significant beneficial effects in patients with osteoarthritis by reduction of clinical symptoms, pain relief and reduction of serum CTX-I, CTX-II, MMP-3 and COMP.
Highlights
Osteoarthritis is a disease characterized by degeneration of the joints
There were no significant differences in Lequesne index, Lysholm score and Visual analogue score (VAS) score between the treatment and control patients
It has been shown that meloxicam and glucosamine sulfate can relieve pain and swelling in knee osteoarthritis patients through significant control effect on advanced cartilage necrosis [9]
Summary
Osteoarthritis is a disease characterized by degeneration of the joints. It usually occurs in middle-aged people and elderly people aged over 50 years old. Glucosamine sulfate is important for the repair and improvement of degenerated cartilage, and it is effective in the etiological treatment of osteoarthritis [3]. There were 20 male patients and 24 female patients, aged 45 to 78 years old (mean age = 62.19 ± 3.13 years). The course of disease in the treatment group was 5 to 17 years (mean course = 7.69 ± 2.63 years). The treatment group was treated with glucosamine sulfate capsules (Shanxi Tongda Pharmaceutical Co., Ltd., batch number 20150107) 0.5 g (two pills, 0.25 g per pill), three times a day, in addition to meloxicam. Lysholm scores were increased in both groups after treatment, but the increase was higher in the treatment group Values of p < 0.05 were assumed to indicate statistical significance
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