Abstract
The present study was undertaken to evaluate the therapeutic effects of Huzhang-Guizhi herb pair (HG), firstly included in Hu-Zhang Power documented in Taiping Shenghui Fang, on monosodium urate (MSU) crystals-induced gouty arthritis in rats. We found that pretreatment with HG in rats with gouty arthritis could significantly attenuate the ankle joint swelling, and this beneficial antigout effect might be mediated, at least in part, by inhibiting tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) production in synovial fluid as well as nuclear transcription factor-κB p65 (NF-κB p65) protein expression in synovial tissue. Moreover, metabonomic analysis demonstrated that 5 and 6 potential biomarkers associated with gouty arthritis in plasma and urine, respectively, which were mainly involved in energy metabolism, amino acid metabolism, and gut microbe metabolism, were identified. HG could reverse the pathological process of MSU-induced gouty arthritis through regulating the disturbed metabolic pathways. These results provided important mechanistic insights into the protective effects of HG against MSU-induced gouty arthritis in rats.
Highlights
IntroductionAn ancient and common form of inflammatory arthritis, is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate, MSU) in tissues and fluids within the body
Gout, an ancient and common form of inflammatory arthritis, is a rheumatic disease resulting from deposition of uric acid crystals in tissues and fluids within the body
HG could remarkably reduce the intumesce index to previous studies [18,19,20] and the Chenomx nuclear magnetic resonance (NMR) suite in rats with monosodium urate (MSU)-induced gouty arthritis (P < 0.05)
Summary
An ancient and common form of inflammatory arthritis, is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate, MSU) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and dietary changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis [1]
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