THERAPEUTIC EFFECT OF TWO FLUORIDE VARNISHES INTENSIVE MODE ON WHITE SPOT LESIONS (RANDOMIZED CLINICAL TRIAL)

Abstract

Background: Fluoride varnish has been used as therapeutic agent for white spot lesions. Bio-active calcium and phosphate was included in the varnish in order to provide better subsurface remineralization. One of the most promising modifications is the addition of casein phosphopeptide amorphous calcium phosphate to fluoride varnish (MI varnish). Objectives: Evaluate the therapeutic effect of intensive application of casein phosphopeptide amorphous calcium phosphate fluoride (CCP-ACPF) varnish and fluoride varnish on the activity of enamel white spot lesions (WSLs) in primary teeth over a 6 weeks follow-up period. Materials and Methods: Forty-four participants with at least 4 active WSLs each were divided randomly into two groups. Test group (22 participants) received three times intensive professional application of MI varnish with two weeks apart. Control group (22 participants) received three times intensive professional application of Duraphat with two weeks apart. Lesions’ activity in both groups was assessed using DIAGNOdent and visio-tactile lesion activity index at baseline and at 6 weeks. Results: Both groups had a significant decrease in mean DIAGNOdent scores and number of active WSLS when compared to their baseline mean score. However when comparing the results of both groups, the control group (Duraphat varnish) had a significant decrease in DIAGNOdent mean score and number of active WSLs when compared to the test group (MI varnish). Conclusions: Intensive application of fluoride varnish decreases caries lesion activity which may lead to the arrest of the early caries lesions. Duraphat varnish is superior to MI varnish in remineralization of early caries lesions.