Abstract
Purpose: To evaluate the therapeutic effect of teriparatide in combination with low-frequency pulsed electromagnetic field in the management of hip fracture.Methods: Patients with hip fracture internal fixation and under conventional postoperative basic adjuvant therapy were compared with those patients who received teriparatide combined with low frequency pulsed electromagnetic field after operation. The content of Bone-Specific AlkalinePhosphatase (BALP), type I Procollagen Carboxy Terminal Propeptide (PICP), serum bone glaprotein (BGP), Ca2+, hip function and degree of bone scab formation were evaluated using Harris score and Fernadez-esteve scoring system. Kaplan-Meier survival curve was plotted to analyze differences in short-term prognosis of different postoperative adjuvant treatment measures.Results: Harris score of the hip joint and the effect of bone formation in the experimental group were higher than that of the control group. The blood levels of BGP, BALP, PICP and serum Ca2+ in the experimental group were higher than that of the control group (p < 0.05). The plotted Kaplan-Meier survival curve indicates that the prognosis of the experimental group was better than that of control group (p < 0.05).Conclusion: The adjuvant therapy of teriparatide combined with low-frequency pulsed electromagnetic field can improve the recovery function and enhance the prognosis of patients who underwent hip fracture surgery.
 Keywords: Teriparatide; Low frequency pulsed electromagnetic field, hip fracture
Highlights
Hip joint is the important joint in the body that supports the body weight when there is a movement
The experimental group was treated with routine postoperative treatment and additional auxiliary treatment i.e., teriparatide added in the treatment regimen in combination with low-frequency pulsed electromagnetic field
It was found that teriparatide improved the therapeutic effect of hip joint surgery compared to the traditional method of supplementing calcium and vitamins after surgery
Summary
Hip joint is the important joint in the body that supports the body weight when there is a movement. Based on the magnitude of the fracture or impact, the movement of hip joint becomes limited and exhibits symptoms, for instance, pain [1,2,3]. The anatomical position of the hip joint is deep and internal fixation is generally used to treat it [4,5]. Despite the effective treatment of internal fixation, some patients still suffer from postoperative loosening and poor fracture healing [2,6]. Anti-osteoporotic drugs can be used together with the usual regimen for patients who underwent hip joint surgery
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