Therapeutic effect of simvastatin on rats with pre-eclampsia

Abstract

Objective To study the effect of simvastatin on the nitrogenm onoxide (NO) concentration in rats with pre-eclampsia.Methods Thirty SD rats were selected and divided into three groups: normal pregnancy group,pre-eclampsia model group and simvastatin group (10 rats in each group).We used endotoxin to set up the pre-eclampsia model rats on gestation 14th day and simvastatin to treat these rats.The 24 hour urine protein on gestation 8th,15th,19th days were determined,as well as the heart rate,blood pressure on gestation 10th,15th,19th days.Nitrate reductase method was used to determine the plastion between the simvastatin [(73±20 )μg],pre-eclampsia [(464±57) μg],and normal pregnancy [(140±12)μg]groups were significant differences in blood pressure(which is equal to the value of blood pressure of pregnancy 19th day subtracting that mong the three groups(which was equal to the value of heart rate of pregnancy 19th day subtracting that of pregnancy 10th day,8th day) among the three groups(P＜0.01),and the value of normal pregnancy group was(158±31) mmol/L,pre-eclampsia model group(49±36)mmol/L,simvastatin group ( 162±14)mmol/L.Conclusions Simvastatin can elevate the level of NO concentration and decrease the blood pressure and urineprotein,but not the heart rate in pre-eclampsia model rats,which suggests that simvastatin maybe used to treat pre-eclampsia. Key words: Pre-eclampsia; Simvastatin ; Nitricoxide; Rats