Abstract
Rumex japonicus Houtt. (RJ) is traditionally used in folk medicines to treat patients suffering from skin disease in Korea and other parts of East Asia. However, the beneficial effect of RJ extract on atopic dermatitis (AD) has not been thoroughly examined. Therefore, this study aimed to investigate the anti-inflammatory effects of RJ on AD in vitro and in vivo. Treatment with RJ inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) as well as the activation of nuclear factor-kappa B (NF-κB) in tumor necrosis factor-α (TNF-α) stimulated in HaCaT cells. The five-week-old Balb/c mice were used as an AD-like mouse model by treating them with 1-chloro-2, 4-dinitrobenzene (DNCB). Topical administration of RJ to DNCB-treated mice significantly reduced clinical dermatitis severity, epidermal thickness, and decreased mast cell and eosinophil infiltration into skin and ear tissue. These results suggest that RJ inhibits the development of AD-like skin lesions by regulating the skin inflammation responses in HaCaT cells and Balb/c mice. Thus, RJ may be a potential therapeutic agent for AD.
Highlights
Atopic dermatitis (AD) is a multifactorial skin disease, with complex interactions
We previously reported that Rumex japonicus Houtt. (RJ) had a hair growth-promoting effect via mitogen-activated protein kinases (MAPKs) and Wnt/β-catenin pathways in human keratinocytes (HaCaT) and mice [12]
The RJ extract had no cytotoxic effect at a concentration of 50 μg/mL for 24 h, but as shown in Figure 2A, the viability of cells treated with an RJ concentration of 1600 μg/mL declined by about
Summary
Atopic dermatitis (AD) is a multifactorial skin disease, with complex interactions. Various factors, including immunological abnormalities, contribute to the pathogenesis and development of AD [1].The early onset of AD in infancy results in it being the most prevalent chronic skin disorder in childhood and can affect individuals throughout their lifetimes [2]. Atopic dermatitis (AD) is a multifactorial skin disease, with complex interactions. Various factors, including immunological abnormalities, contribute to the pathogenesis and development of AD [1]. The early onset of AD in infancy results in it being the most prevalent chronic skin disorder in childhood and can affect individuals throughout their lifetimes [2]. The common symptoms of AD include dry, inflamed skin, intense pruritis, itching and skin hypersensitivity. AD can cause recurring rashes, persistent scratching, erythematous plaques, and small bumps like blisters that may leak extracellular fluid. AD causes sleep disturbance which may leads to insomnia, psychological and emotional distress, and low quality of life [3,4,5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
