Abstract
Marrubium vulgare L. leaves have long been recognised in Moroccan traditional medicine for their effectiveness in managing pain and inflammation. However, their potential is in treating peripheral neuropathic pain. This study aimed to investigate the effects of M. vulgare aqueous extract (AEMV) on peripheral neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in mice. This research represents the first exploration of AEMV’s therapeutic potential in neuropathic pain management. AEMV was initially analysed using HPLC MS/MS to identify its predominant compound, Marrubiin. Mice underwent CCI surgery to induce neuropathic pain. AEMV was administered orally and Clomipramine served as a positive control. Chronic administration of AEMV significantly attenuated thermal, mechanical, and cold sensitivity induced by CCI. It also promoted functional and histological recovery of the sciatic nerve.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
