Abstract
Therapeutic Effect of Intravenously Administered Autologous Adipocyte-Derived Stem Cells on Chronic Stage Stroke Patients
Highlights
To overcome the limited application of thrombolytic or surgical endovascular therapies for patients with ischemic stroke, a number of preclinical studies of animal models and human clinical trials with intravenous transplantation of mesenchymal stem cells have been performed
Aim: In the present study, we aimed to clarify the effect of autologous adipose-derived stem cells (ADSC) on chronic stroke patients who were treated with ADSC intravenous drip-infusion later than 4 months after stroke onset
Patients who treated with ADSC drip infusion within 6 months after stroke onset exhibited more apparent functional recovery compared with patients who were treated with ADSC later than 12 months after stroke onset
Summary
To overcome the limited application of thrombolytic or surgical endovascular therapies for patients with ischemic stroke, a number of preclinical studies of animal models and human clinical trials with intravenous transplantation of mesenchymal stem cells have been performed Those results have been reported to be effective, safe and promising in the recovery of clinical outcomes of stroke patients at acute and subacute stages, but clinical studies at chronic stages are still limited [1,2,3,4]. In 2011, Honmou, et al [6] reported that a single intravenous transplantation of autologous human mesenchymal stem cells derived from bone marrow and expanded in human serum was effective and safe to reduce and improve the functional outcome in 12 stroke patients of ischemic grey matter, white matter and mixed lesions. Clinical studies on stem cell therapy of stroke reported previously, did not describe the details of functional changes during and immediately after the end of intravenous stem cell transplantation
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