Therapeutic Effect of Epidermal Growth Factor Combined With Nano Silver Dressing on Diabetic Foot Patients.

Kaihua Zhang,Jiarui He,Jiasheng Xu,Qingfu Zeng,Riwei Wang,Yiran Li,Shasha Wan,Yanhua Wan

doi:10.3389/fphar.2021.627098

Abstract

Objective: To investigate the clinical efficacy of epidermal growth factor combined with nano silver dressing in the treatment of diabetic foot wounds. Methods: A total of 160 patients with diabetic foot ulcers admitted to the Second Affiliated Hospital of Nanchang University from 2015-06 to 2018-06 were selected to participate in the experiment. A randomized table method was used to randomly divide 160 patients into 4 groups: 40 in the epidermal growth factor group, 40 in the nano-silver dressing group, 40 in the combined group, and 40 in the saline control group (normal saline). The healing stage of the wound surface and the growth degree of granulation tissue were graded. Each group was given a dressing change every other day, and the time required for wound repairing to each healing stage was observed. After 2 and 4 weeks of treatment, the wound exudate was collected for bacterial culture. Results: There was no significant difference in the time between the four groups of patients reaching the effective phase of treatment (level 1). Compared with the control group, the epidermal growth factor group and the combined group achieved a shorter time for wound repairing to healing stages 2 and 3, and the difference was significant (p < 0.05). The combined group had a shorter wound repairing time than the epidermal growth factor group (p < 0.05). Compared with the control group, the positive rate of bacteria in the combined group and the silver nanoparticles group was significantly lower after 2 and 4 weeks of treatment. Conclusion: There is no significant difference in wound healing between the four groups during the clinically effective period. After this period, the combined use of recombinant epidermis Growth factors and nano-silver dressings have a significant effect on promoting wound healing and can effectively prevent infection.

Highlights

Diabetic foot is a serious diabetic complication (Huang et al, 2015) with high clinical incidence which can cause disability and seriously affect the life and health of patients
For patients who had been diagnosed with diabetes, the patient should be asked about the type of clinical medication, the number of medications, and blood glucose control, the patient’s blood glucose profile should be measured, and the clinical medication adjusted in time
In grades 1, 2, and 3, the bacterial count level of the combined group and the silver nanoparticles group were all lower than that of the control group, and there was no significant difference between the bacterial count of the epidermal growth factor group and the control group

Summary

Introduction

Diabetic foot is a serious diabetic complication (Huang et al, 2015) with high clinical incidence which can cause disability and seriously affect the life and health of patients. The amputation rate of diabetic foot is reduced to a certain extent, but there are still many diabetic foot patients whose wounds are difficult to heal and the incidence of wound infection is high (Li et al, 2016; Zhang et al, 2016), so it is necessary to explore a more reasonable treatment plan. Epidermal growth factor has been widely used in the clinical treatment of diabetic foot, but there are very few clinical studies on the treatment of epidermal growth factor combined with nano silver dressing. This study designed a control experiment to observe the effect of epidermal growth factor and nano-silver dressings on the treatment of diabetic foot alone and to compare the therapeutic effects after the combination of the two, to determine the therapeutic effect of diabetic foot wounds treated with epidermal growth factor combined with nanosilver dressing

Methods

Results

Discussion

Conclusion