Abstract

 
 
 
 Purpose: The present study analyzes the comprehensive therapeutic effect of cycloserine, in combination with anti-tuberculosis drugs using chest X-ray and chest CT (computed tomography) scan techniques.
 Methods: A total of 90 patients, diagnosed with multidrug resistant tuberculosis (MDR TB) were subjected to chest x-ray and CT scan before and after treatment in the two groups. Different views such as sagittal, coronal, lung window and multiplanar imaging of mediastinal window were taken. Some parameters such as case detection rate (CDR) in chest X-ray and CT scan and comprehensive curative effect were observed in two groups. Further, the changes in chest CT signs in addition to absorption of focus, cavity closure and changes in CT extra pulmonary signs were also observed.
 Results: The clinical profile of the patients and the course of disease were statistically insignificant (p > 0.05). Total effectiveness rate and case detection rate (CDR) values exhibited a significant difference between the groups (p < 0.05). Lung consolidation, nodules and cavities significantly improved in both groups before and after the treatment (p < 0.05). Both groups showed significant improvements in extrapulmonary signs in CT scan (p < 0.05) after the treatment.
 Conclusion: Based on the study outcomes, the CT scan method has good potentials for diagnosing and treating MDR TB at the early stages. Further, it can clarify the signs and outcomes of the disease at early stages, thus providing the medical fraternity a great opportunity to cure the disease.
 
 
 
Highlights
Tuberculosis (TB), a chronic infectious disease, is caused by Mycobacterium tuberculosis among human beings which remained the main cause of death globally in the year, 2019 [1]
An approximate of two billion people gets infected with Mycobacterium tuberculosis while 10 million new active tuberculosis patients are recorded with 1.7 million deaths every year [2]
When Mycobacterium tuberculosis is resistant to first-line antituberculosis drugs such as rifampicin and isoniazid, it can be treated with second-line drugs, which have better efficacy and less toxicity [5]
Summary
Tuberculosis (TB), a chronic infectious disease, is caused by Mycobacterium tuberculosis among human beings which remained the main cause of death globally in the year, 2019 [1]. An approximate of two billion people gets infected with Mycobacterium tuberculosis while 10 million new active tuberculosis patients are recorded with 1.7 million deaths every year [2]. Multidrug-resistant TB accounts for almost 25% of global TB death.
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