Therapeutic effect of continuous arterial catheter directed thrombolysis on lower limb arterial ischemic disease

Abstract

Objective To investigate the clinical efficacy of continuous arterial catheter directed thrombolysis for ischemia disease of lower extremity. Methods Retrospective analysis of clinical data of 29 patients undergoing continuous arterial catheter directed thrombolysis from June 2016 to June 2018 in Department of Aortic and Vascular Surgery Center, Fuwai Hospital, CAMS&PUMC was conducted. There were 25 males and 4 females, aged (65.3±11.2) years, with an age range of 51-81 years. The patients were diagnosed after admission and received continuous arterial thrombolysis. After thrombolytic therapy, estimate was conducted whether to place the stent further based on the result of angiographit. The patients′ pain symptom relief, embolism, bleeding and other complications were observed in the 6 months, 12 months and 24 months by telephone follow-up or outpatient review. Meanwhile, the patients improved the color Doppler ultrasound examination. Results The 21 patients were markedly effective, 7 patients were effective, and 1 patient was ineffective in all the 29 patients who accepted the continuous arterial catheter directed thrombolysis therapy. Two of the patients developed distal toe arterial embilization during thrombolysis and improved after drug treatment. The total effective rate was 96.5%(28/29). Stents implant rate was 20.7%(6/29). The follow-up rate was 86.2%(25/29). No symptom relapse was observed. Conclusion Continuous arterial catheter directed thrombosis for ischemia disease of lower extremity is minimally invasive, safe and effective. Key words: Catheterization; Ischemia; Arteries