Therapeutic effect of combined drug therapy on knee joint of Kaschin-Beck disease

Abstract

Objective To investigate the effect of knee joint injection of sodium hyaluronate combined with oral administration of diacerein and/or glucosamine sulfate on knee joint of Kaschin-Beck disease. Methods The method of prospective study was used, 80 patients with Kaschin-Beck disease admitted to the General Internal Medicine, Guang'an People's Hospital from January 2015 to December 2017 were selected as subjects. They were divided into 4 groups according to the difference of their medication methods, 20 cases per group. Group A was treated with intra-articular injection of sodium hyaluronate, Group B was treated with intra-articular injection of sodium hyaluronate + oral diacerein, Group C was treated with intra-articular injection of sodium hyaluronate + oral glucosamine sulfate, Group D was treated with intra-articular injection of sodium hyaluronate + oral diacerein and glucosamine sulfate, and the overall therapeutic effects of the 4 groups were compared. Results The knee joint scores of Group D at 7, 14, 90, and 180 days after treatment were (6.25 ± 2.01), (4.22 ± 1.15), (2.21 ± 1.01), and (1.15 ± 0.15) scores, respectively, they were significantly lower than those of Group A [(12.11 ± 3.02), (11.91 ± 2.98), (11.85 ± 2.85), (11.05 ± 2.52) scores], Group B [(9.11 ± 2.85), (8.32 ± 2.45), (7.55 ± 2.32), (6.15 ± 2.01) scores] and Group C [(9.12 ± 2.84), (8.23 ± 2.32), (7.43 ± 2.29), (6.11 ± 2.00) scores], the differences were statistically significant (P < 0.05). The total effective rates of the 4 groups were 60% (12/20), 65% (13/20), 70% (14/20), and 90% (18/20), respectively, Group D was significantly higher than those of other 3 groups (χ2 = 18.250, 18.250, 16.000, P < 0.05). The scores of 20 m walking pain and joint tenderness in Group D after treatment and follow-up period were lower than those of other 3 groups (P < 0.05). Conclusions In the clinical practice of Kaschin-Beck disease, intra-articular injection of sodium hyaluronate combined with oral diacerein and glucosamine sulfate can improve the knee joint function of patients, alleviate pain and enhance the overall therapeutic effect. The combined therapy has great clinical value. Key words: Kaschin-Beck disease; Sodium hyaluronate; Diacerein; Glucosamine sulfate; Therapeutic effect