Therapeutic effect of clostridium butyricum combined with zinc preparation on pediatric diarrhea and its effect on inflammatory factors

Abstract

Objective To investigate the therapeutic effect of clostridium butyricum combined with zinc preparation on pediatric diarrhea and its effect on inflammatory factors. Methods Seventy-eight children with diarrhea from March 2016 to March 2018 were randomly divided into two groups: control group (n = 39) and observation group (n = 39). The control group was treated with zinc preparation, and the observation group was treated with clostridium butyricum combined with zinc preparation. And the inflammatory factor level, symptom improvement time, and curative effect were compared between the two groups. Results After treatment, the levels of hs-CRP, IL-8, and IL-6 in the observation group [(2.78±1.64) mg/L, (82.23±6.41) ng/L, (143.92±9.72) ng/L] were significantly lower than those in the control group [(4.13±1.86) mg/L, (101.67±9.18) ng/L, (192.56±9.65) ng/L], the total effective rate (97.44%) was significantly higher than that in the control group (76.92%); the improvement time of symptoms (abdominal pain, vomiting, body temperature) and the time of stool examination returning to normal in the observation group [(1.14±0.32) d, (1.34±0.32) d, (3.24±0.56) d, (5.06±0.52) d] were significantly shorter than those in the control group [(2.34±0.41) d, (2.73±0.42) d, (6.72±1.14) d, (9.35±0.92) d] (P<0.05). Conclusion The treatment of clostridium butyricum combined with zinc preparation can effectively reduce the level of inflammatory factors in children with diarrhea, improve clinical symptoms and the therapeutic effect. Key words: Pediatric diarrhea; Clostridium butyricum; Zinc preparation; inflammatory factors; Symptom improvement