Therapeutic effect of atomoxetine hydrochloride for attention deficit hyperactivity disorder comorbid Tourette syndrome

Abstract

Objective To evaluate the therapeutic efficacy of atomoxetine hydrochloride for attention deficit hyperactivity disorder (ADHD) combined with Tourette syndrome (TS). Methods Twenty-six cases of children with ADHD combined with TS were firstly diagnosed American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-Ⅳ) of ADHD and TS were treated with atomoxetine.The symptoms were improved and conditions were assessed based on the fourth version of ADHD parent rating scale and the severity of Yale comprehensive pumping quantity during pre-treatment, the 2nd, 4th, 6th and the 8th week of therapeutic courses, respectively.The adverse reaction was observed. Results 1.Compared with pre-treatment, attention deficit scores after treatment were statistically different(t=8.41, 9.97, all P 0.05). But at the fourth week of assessment, and the rates of curative effect were respectively 19.23% and 46.15%.It had statistical significance (χ2=3.923, P 0.05).3.During the treatment, no severe adverse reaction had appeared. Conclusions Atomoxetine in ADHD comorbid TS had exact curative effect and no obvious adverse reactions.In the treatment of ADHD, hyperactivity / impulsivity effect is better than the attention deficit.In the treatment of TS, vocal tics onset is better than the motor tics.In comparison of ADHD with TS, TS symptoms improve faster than ADHD in the onset, but the final effect is quite. Key words: Attention deficit hyperactivity disorder; Tourette syndrome; Comorbid; Atomoxetine hydrochloride