Therapeutic Effect of Asphodelus Tenuifolius Against Streptozotocin Induced Diabetic Rats

Abstract

Background: Diabetes mellitus is a long-lasting metabolic disorder that hinders the capability of the body to utilize food properly and is affected day by day through our diet, exercise, infection and stress. Presently, the trend is more towards natural plant-based products containing potential bio-active components than towards conventional medicines. For the purpose, out of numerous herbs used in common medicines, the subfamily of Asphodelus tenuifolius, used for several ailments, anti-inflmmation, anti-hypertension and antidiuretics etc. Objective: The objective of the present study was to evaluate the therapeutic effect of Asphodelus tenuifolius against streptozotocin induced diabetic rats. Method: The current study was based on the in vitro and in vivo properties of Asphodelus tenuifolius. The in vivo study was conducted that includes the TPC, TFC & DPPH. The in vitro study was also administered that includes the body weight and glucose levels of the rats. The thirty rats were divided into six groups; normal control, disease control, drug control, extracts treatment at 250, 500 and 750 mg/kg respectively. Results: The results depicted that the maximum decline in blood glucose levels of the streptozotocin induced diabetic rats were observed in T5. However, the body weights of the diabetic rats were maintained. Conclusion: Conclusively, Asphodelus tenuifolius plants contain a bio-active component that help to reduce hyperglycemia, maintains body weights in streptozotocin induced diabetic rats.