Therapeutic Effect of Amygdalin on Acetic Acid-induced Colitis in Rats: Histopathological and Immunohistochemical Study

Yasser Elbastawisy,Hazem Mohamed

doi:10.21608/eajbsd.2022.216580

Abstract

Therapeutic Effect of Amygdalin on Acetic Acid-induced Colitis in Rats: Histopathological and Immunohistochemical Study

Highlights

Inflammatory bowel disease (IBD) is a progressive disabling inflammatory condition affecting the gastrointestinal tract comprising two main subtypes; ulcerative colitis (UC) which is limited to the colonic mucosa and Crohn’s disease (CD), which may affect any part of the gastrointestinal tract from the mouth to the anus
While colonic mucosa of group III exhibited a relative decline in COX-2 immunopositive cells in comparison to group II (Fig. 4C)
Regarding Inducible nitric oxide synthase (iNOS) immunoreactivity, group II showed a significant increase in the area % (P

Summary

Introduction

Inflammatory bowel disease (IBD) is a progressive disabling inflammatory condition affecting the gastrointestinal tract comprising two main subtypes; ulcerative colitis (UC) which is limited to the colonic mucosa and Crohn’s disease (CD), which may affect any part of the gastrointestinal tract from the mouth to the anus (K Ko &K Auyeung, 2014). UC is the most common form of IBD all over the world characterized by idiopathic, repetitive, and diffuse inflammation of the mucosa of the colon and rectum (Feuerstein & Cheifetz, 2014). It presents with abdominal pain, diarrhea, mucopurulent bloody stools, and weight loss and may proceed, in severe cases, to carcinoma of the colon (Vejzovic, Bramhagen, Idvall, & Wennick, 2018). The production of a cascade of free radicals and an increase in lipid peroxidation leads to reduction of the cellular antioxidant capacity, resulting from the secretion of many inflammatory mediators from migrated granulocytes in the inflamed mucosa which reduces the cellular antioxidant capacity with subsequent colonic inflammation and the progression of the disease (Cetinkaya et al, 2005). Studies on mucosal biopsies confirmed that oxidative stress increased and the antioxidant defense system significantly decreased in patients with IBD (Dutta et al, 2019)

Methods

Results

Conclusion