Abstract
Purpose: To investigate the efficacy of a combination of montelukast and vitamins A and D drops in bronchial asthma children, and its effect on quality of life.Methods: Sixty bronchial asthma children from June 2018 to June 2020 were collected and randomized into study group and control group (30 cases in each group). Control group received montelukast sodium (chewable tablets), while the study group received vitamins A and D drops (capsules) plus. Clinical efficacy, lung function, serum inflammatory factors, and quality of life were evaluated and compared.Results: Compared with control group, total treatment effectiveness was higher and the symptom remission period was shorter in the study group (p < 0.05). Post-treatment, the parameters of FEV1 and FVC increased in both groups, but higher in the study group (p < 0.05). Serum levels of CRP and IL-4 in both groups decreased after treatment, while serum IL-10 levels were significantly up-regulated. Compared with control group, the levels of these indicators were improved in the study group (p < 0.05). Post-treatment Chinese Version of Pediatric Quality of Life Asthma Specific Scale (PedSQL) score was higher than before treatment, with higher values (for all indicators) in the study group (p < 0.05).Conclusion: The combination therapy of montelukast and vitamins A and D drops produces good clinical efficacy in children with bronchial asthma. It significantly shortens the time taken for relief of clinical symptoms, improves lung function, reduces inflammatory response, controls asthma, and improves the quality of life of the patients.
Highlights
Bronchial asthma, a type I allergic disease of the respiratory tract in pediatrics, is an inflammatory airway disease mediated by mast cells, eosinophils and lymphocytes [1]
The present study was carried out to investigate the clinical effects of combination of montelukast and vitamins A & D drops on children with bronchial asthma
The PedSQL was used to assess the quality of life of children aged 5-12 years, including four aspects: symptom, anxiety, treatment and communication, with the total score calculated as average of scores of all the items answered: the higher the score, the higher the quality of life [8]
Summary
A type I allergic disease of the respiratory tract in pediatrics, is an inflammatory airway disease mediated by mast cells, eosinophils and lymphocytes [1]. Children with asthma repeatedly have chest tightness, cough, shortness of breath, wheezing and other symptoms, which seriously affect their growth and development, physical and mental health, and quality of daily life [2]. There is clinical need to strengthen asthma control, enhance lung function, and improve the quality of life of asthmatic children. The incidence of asthma is increasing year by year in China. It affects the quality of life and growth of children, it seriously affects their physical and mental health [5]. The present study was carried out to investigate the clinical effects of combination of montelukast and vitamins A & D drops on children with bronchial asthma
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