Therapeutic effect evaluation on the treatment of acute upper gastrointestinal bleeding with freezing Zidi mixture lavage

Abstract

Objective To observe the clinical effects of treating acute upper gastrointestinal bleeding（AUGIB） with freezing Zidi mixture lavage. Method 183 UGIB patients from the First Affiliated Hospital to Guanzhou University of TCM in August 2013 were randomly recruited into a control group with 91cases and a treatment group with 92 cases. The treatment group was treated with intragastric administration of freezing Zidi mixture, while the control group was treated with intragastric administration of cryohydrate and norepinephrine. The changes of clinical effects, blood pressure, hemoglobin, blood urea nitrogen, pulse and dark stool were observed and the bad emotions as anxiety, depression and fear were evaluated. Results ① On therapeutic effect, the total effective rate was 96.7% and 85.7% in the treatment group and the control group respectively, with statistical difference（χ^2=2.943,P〈0.05）. ② On the time of symptom disappearance：the disappearing time of vomiting, dark stools and occult blood test in the treatment group was obviously shorter than the control group after the treatment（t=6.628、14.052、21.706,P〈0.05 or 0.01）. ③ On body symptom changes： after the treatment, the systolic pressure, heart rate, hemoglobin, and blood urea nitrogen [（114.3±12.1）mmHg,（78.6±11.4）/min,（98.1±10.5）g/L,（5.9±1.1）mmol/L] in the treatment group were all obviously improved than those [（106.3±11.2）mmHg, （88.7±12.1）/min,（88.2±11.7）g/L,（6.9±1.4）mmol/L] in the control group;body temperature returned to normal in both groups, and there was no statistical difference score was either in or between groups（P〉0.05）. ④ On changes of anxiety, depression and fear：the treatment group [the（42.5±9.4）, （41.6±9.7）, （26.3±5.4）for each]was obviously improved after the treatment than the control group[the score was（51.2±10.1）,（50.4±11.5）,（30.4±6.9）for each],P〈0.05. Conclusion Freezing Zidi mixture lavage can obviously elevate systolic pressure, decrease heart rate, enhance hemoglobin, decrease blood urea nitrogen, relieve body stress reaction and other clinical symptoms. Its effects were better than intragastric administration of cryohydrate and norepinephrine in treating AUGIB. Key words: Freezing Zidi mixture; AUGIB; Intragastric administration