Therapeutic Clinical Implications of Insulin Resistance (IR) in Polycystic Ovary Syndrome (PCOS) in Lean/Obese PCOS PatientsDevelopment of Non-alcoholic Fatty Liver Disease (NAFLD)-A Narrative Review

Abstract

Polycystic ovary syndrome (PCOS) portrays a common which impacts the reproductive capacity as well as causes irregular menstrual cycles. Apart from criteria set at the time of Rotterdam syndrome ESHRE/ASRM-sponsored PCOS consensus, in the last decade, a newer problem insulin resistance (IR) has been observed more commonly along with subjects having PCOS greater IR in view of different for instance overweight in addition to obesity, however clarification is lacking in patients with PCOS who are of normal weight, thereby validating the posit that IR takes place independent of weight. It has been confirmed by proof that there is existence of the complicated pathophysiological conditions taking place resulting in dysfunctional post insulin receptor signalling particularly in PCOS patients having familial diabetes. Furthermore PCOS patients documented a greater incidence of non-alcoholic fatty liver disease (NAFLD) associated with hyperinsulinemia, which was observed to be greater in obese subjects having PCOS. Here in this narrative review we have concentrated on how as a further corollary to the in-depth work of the group of Genazzani AD; applications might be made with regards to utilization of very low-calorie ketogenic diet (VLCKD) along with Mediterranean diet (MD) for the treatment of PCOS apart from part of the glycaemic index in addition to glycaemic load in the generation of PCOS as well as prevention of its complications as well as trans generational transmission to the progeny.