Abstract

Background and Objective:NAFLD affecting up to 30% of the population globally. Drug treatment options are limited with disappointing results. The dietary supplementation in the form of green tea is another option. Our objective was toinvestigate the effect of Green tea extract (GTE) supplementation on various parameters innon-alcoholicfatty liver disease (NAFLD) patients.Methods:This study was conducted Dept. of Medicineof Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from 15 April 2016 to 15 July 2016. Eighty overweight, non diabeticand dyslipidemic patients of NAFLD, diagnosed on the basis of ultrasound and aminotransferases level were randomized for treatmentwith capsule GTE500mg (n=40)and capsule placebo (n=40) twice a day for twelve weeks. Anthropometric parameters, liver enzymes, inflammatory markers and liver ultrasound imaging were estimated by SPSS-16 pre and post treatment.Results:As compared to placebo, GTE caused a significant improvement in body weight (29.5±3.8 to 27.2±3.2 kg/m2 p=0.03), BMI (86±10.5 to 80±12.4 kg p=0.026), HOMA-IR(4.32±2.25 to 3.16± 1.6 p=0.0081) lipid profile (i.e. TC: L242.5±20.5 to 215.4±18.6 mg/dl p=0.005; TG: 175±22.6 to145±18 mg/dlp=0.003; LDL-C:155±12.5 to 140±16.7 mg/dl p=0.011; HDL-C: 36.8±6.7 to46.4±5.8 mg/dl p =0.001, Aminotransferases (i.e. ALT: 70.4±15.8to52.8±12.2 IU/L p=0.04; AST: 65.8±12.4 to 44.3± 8.5U/L p =0.002) and Inflammatory markers (hs-CRP: 3.14±0.58 to 2.18±0.32 p =0.023 Adiponectin: 8.46±1.02 to 10.55±3.42μg/ml p =0.003)GTE also caused a 67.5% regression of fatty liver changes on ultrasound as compared to placebo which is 25%only.Conclusion:GTEtherapy resulted in significant improvement in metabolic, chemical, inflammatory and radiological parameters of non-alcoholic fatty liver disease patients who were non-diabetic anddyslipidemic.

Highlights

  • Non alcoholic fatty liver disease (NAFLD) is foremost cause of progressive liver disorder worldwide

  • NAFLD is a benign disease but if it cannot controlled appropriately it may progress to non alcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis of liver, cardiovascular disorders, kidney diseases and is predicted to become the most common indication of liver transplantation by 2030.4

  • In addition green tea has beneficial effect on all NAFLD associated medical conditions such as obesity, metabolic syndrome,[12] hypertension and dyslipidemia[13] in various clinical studies. In this placebo controlled trials we evaluate the effect of green tea extract (GTE) on various anthropometric, chemical, metabolic, inflammatory and radiological parameters in NAFLD patients who are non diabetic as well as dyslipidemic in order to see its independent effect in non diabetics

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Summary

Introduction

Non alcoholic fatty liver disease (NAFLD) is foremost cause of progressive liver disorder worldwide. It has strong association with obesity 41-61%, Correspondence: February 16, 2017 June 28, 2017 July 7, 2017 metabolic syndrome 30-56%, Type-2 diabetes 1828%, dyslipidemia 52-83% and hypertension 1546%.These risk factors promote NAFLD as a global heath issue in western countries with a prevalence rate of about 20-30%. Our objective was to investigate the effect of Green tea extract (GTE) supplementation on various parameters in non-alcoholic fatty liver disease (NAFLD) patients. Conclusion: GTE therapy resulted in significant improvement in metabolic, chemical, inflammatory and radiological parameters of non-alcoholic fatty liver disease patients who were non-diabetic and dyslipidemic

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