Abstract

Recently, Pahor et al. (1) presented a meta-analysis based on four studies assessing whether ACE inhibitors are superior to alternative agents for the prevention of cardiovascular events in patients with hypertension and type 2 diabetes. The four eligible trials were as follows: 1 ) the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET), 2 ) the Appropriate Blood Pressure Control in Diabetes Trial (ABCD), 3 ) the Captopril Prevention Project (CAPPP), and 4 ) the U.K. Prospective Diabetes Study (UKPDS) (2,3,4,5). FACET's study lasted only 2.8 years, whereas the other studies lasted 5, 6.1, and 8.4 years, respectively. All of the trials were blind except for FACET. The primary end points of FACET were serum lipids and glucose metabolism, whereas the primary …

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