Abstract
Diabetes, a metabolic disorder characterized by elevated fasting blood glucose levels, affects nearly 8% of the world population and was predicted that it would be the top seven leading cause of death in the next ten years. The incidence of diabetes and its morbidity are increasing rapidly in developing countries due to lifestyle change and intake of high-calorie diet occurring with urbanization. Medicinal plants and their products have been proven to be effective, less expensive, and safe for the treatment and prevention of diabetes. Although several medicinal plants known for the antidiabetic property are reported in the ancient medical textbook, there is always a scope to identify and validate less explored medicinal plants that are still practiced regularly by local and tribal people since ancient times. Here, in the present article, we would like to review a less explored medicinal plant, Dillenia indica, which has promising effects in treating diabetes and other diabetic-associated complications. In spite of its wide use in the Northeast region of India as traditional medicine, there is only one clinical study where the antidiabetic potential of the fruit powder has been shown. Further well-designed animal and human studies are needed to confirm the role of Dillenia indica in diabetes and its associated complications.
Highlights
Diabetes mellitus (DM) is a chronic metabolic complication associated with the incidents of glucose intolerance and hyperglycemia
An effort has been made to cover the use of Dillenia indica in diabetes and its associated complications, and the various mechanisms by which this plant shows its beneficial effects (Figure 2)
Scientific literature has proved the belief of using traditional herb, Dillenia indica, in the treatment of diabetes and its associated complications
Summary
Diabetes mellitus (DM) is a chronic metabolic complication associated with the incidents of glucose intolerance and hyperglycemia. Diabetes is a chronic and complex disease involving multiple morbidities that requires the attention of multiple health care providers or facilities [2]. It is one of the world’s major health problems and predicted that it would be the top seven leading cause of death in the ten years. Elevated blood glucose levels caused an additional 2.2 million death by increasing the risk of cardiovascular disease and associated complications. Diabetes and its associated complications increase the overall risk of a fatal death. Explored several medicinal plants contain various substances with unique beneficial effects on diabetes and its associated complications. In the present review, we are going to discuss the use of Dillenia indica, an Indian traditional plant, in diabetes and its potential for antidiabetic therapy in the future
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