Abstract
The aim of this presentation is to demonstrate the pathological importance of microenvironmental tissue hypoxia and to elucidate a general treatment concept for this situation which we have termed therapeutic angiogenesis 1. Hypoxia not only represents an insufficient oxygen supply for the cells of a given tissue area but is also regarded as an indicator for their metabolic deprivation and the concomitant accumulation of waste products. Therapeutic angiogenesis applied either with clinically established methods or using novel ways, which are the objectives of laboratory research and clinical trials at present, or in so far hypothetical forms, should lead to an expansion of the functional microvascular space resulting in an increased nutritive blood flow. Thus microregional oxygen availability should be elevated and directly counteract local tissue hypoxia. The problems of nutritional deprivation and waste product accumulation are also treated by therapeutic angiogenesis.
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