Abstract
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.
Highlights
Plasmodium vivax is the most widespread human malaria parasite
We confirm that DHA/PPQ acts faster (2 months [11]
The number of patients enrolled was small, we demonstrated that DHA/PPQ acts faster (
Summary
Plasmodium vivax is the most widespread human malaria parasite. Almost 2.5 billion persons are at risk for infection in >90 countries [1,2]. After we obtained written informed consent, we fed batches of 50 An. dirus mosquitoes with blood collected from these patients on 3 occasions: 1) before the first dose of DHA/PPQ or chloroquine, 2) on the same day at 9:00 pm (i.e., 2–11 h after treatment), and 3) at 24 h posttreatment for patients treated with chloroquine. Proportion of infectious patients after first dose of treatment; feeding assay at 9:00 PM
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