Abstract
Therapeutic alternatives for the treatment of ocular toxoplasmosis
Highlights
Ocular toxoplasmosis is caused by Toxoplasma gondii, an intracellular parasite
In Brazil, 80% of the infectious posterior uveitis cases were associated with ocular toxoplasmosis (Oréfice et al, 2005)
The existence of an extensive therapeutic regimen based on drugs capable of inducing significant systemic side effects and/or toxicity, the T. gondii resistance against the drugs administered in the therapy, and the possibility of recurrence of the ocular lesions, causing the partial or total visual loss are some of the reasons explaining the therapeutic failure of the ocular toxoplasmosis and highlight the necessity to develop new drugs and new pharmaceutical dosage forms to effectively eliminate this disease
Summary
Ocular toxoplasmosis is caused by Toxoplasma gondii, an intracellular parasite. T. gondii induces the formation of lesions in the delicate ocular tissues of the posterior segment of the eye. Even in these patients, during primary infection, the ocular toxoplasmosis can manifest, leading to necrotizing retinitis with secondary choroiditis, occurring adjacent to a retinochoroidal scar, and is associated with retinal vasculitis and vitritis (Butler et al, 2013).
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