Abstract
Staphylococcus aureus is a gram-positive pathogen that can cause peripheral to serious infections in almost all tissues, especially in immunocompromised people, since the introduction of the first antimicrobial agents, it has evolved into one of six “ESKAPE” pathogens that are responsible for the majority of nosocomial infections and able to escape the biocidal action of antibiotics with high resistant rate and pass it into other bacteria. This evolutionary ability of S. aureus to gain resistance, has made it important to get insight into resistance mechanisms to be able to develop new antimicrobial agents. Lemon is a flowering medicinal plant belongs to the family Rutaceae, which contains different antimicrobial components. Nanotechnology has enabled the use of nanoparticles for the treatment of antimicrobial-resistant bacteria. Gold nanoparticles have been reported for their most desirable properties as compared to any other noble metal-based nanoparticles, Titanium dioxide NPs have also been explored as metallic NPs and have been successfully applied in MRSA therapy. This study aimed to study the inhibitory effects of fresh sour and sweet lemon juices plus gold titanium dioxide nanoparticles against multidrug resistant Staphylococcus aureus. A total of (110) different clinical samples had been collected from hospitals looking for Staphylococcus aureus isolates.
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