Therapeutic Administration of Allergen-specific CD4 +CD25 + Regulatory T Cells Suppresses Chronic Allergen-induced Airway Inflammation and Remodelling in a Murine Model

Abstract

RATIONALE: CD4+CD25+ regulatory T cells can inhibit excessive immune responses in vivo. We have previously demonstrated that prophylactic administration of allergen-specific CD4+CD25+ regulatory cells suppressed acute allergen-induced airway inflammation in a murine model. In the present study, we sought to determine the effect of therapeutic administration of regulatory T cells in a model of chronic allergen-induced airway disease