Abstract
The concept of therapeutic and diagnostic activities is mainly concerned to medical and pharmaceutical sciences. However, the recent trends earmarked the synergistic approaches of science and technology to provide more vibrant and effective medical treatment for the solution of health complications in medical sciences and it’s the genesis of modern medical diagnostic. Hence, medical research is directed towards most promising and challenging fields of therapeutics + diagnostics = theranostics. The feasibility of theranostics nowadays is apprehended in various disease diagnostics and curing processes. The modern medical diagnostic techniques are based on molecular imaging where each technique has its own characteristics, merits and demerits and most of the imaging modalities are complementary to each other. To provide better results of imaging the theranostic agents play very important role. The useful biopolymer research has been assisted towards the evolution of improved imaging agents in the form of quantum dots, nanoparticles and other new regenerative medication. The mini review focuses on theranostic development with special emphasis on quantum dots, and nanoparticles in the light of biopolymer, chitosan for cancer diseases.
Highlights
Nano-theranostics involves the synthesis and application of numerous nanoparticle carriers, such as polymer systems, dendrimers, metal and non-metallic nanoparticles, polymeric nanocomposites and carbon nanotubes, for immediate, controlled and targeted delivery of therapeutic agents in order to achieve better results with fewer side effects [4]
The concept of personalized medicine has recently emerged as a promising way to address unmet medical needs especially in cancer treatments
Quantum Dots (QDs) FRET studies was studied using confocal microscopy at different time intervals after transfection in Human Embryonic Kidney 293 (HEK293) cells to study unpackaging of chitosan -p DNA aggregates. These analysis indicates that at 24 h after transfection, polyplexes were bounded in the perinuclear domain, whereas at 72 h post-transfection, polyplexes were disengaged and DNA was located in the nucleus without any signal emitted from chitosan (Cy5) [26]
Summary
Nano-theranostics involves the synthesis and application of numerous nanoparticle carriers, such as polymer systems, dendrimers, metal and non-metallic nanoparticles, polymeric nanocomposites and carbon nanotubes, for immediate, controlled and targeted delivery of therapeutic agents in order to achieve better results with fewer side effects [4]. The present review will describe in brief the different imaging techniques, diagnostic agents and role of chitosan for the development of theranostics with reference to quantum dots, and nanoparticles for cancer treatment.
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