Abstract
A satisfactory mathematical description of gas-liquid partition capillary chromatography is desirable for design and optimization of separation processes, as well as for determination of physical properties. A mathematical model is presented that includes the effects of mass transport in the mobile and stationary phases, assumes equilibrium at the gas-liquid interface, and accounts for axial dispersion of solute. Interphase mass transfer is included, and is found to be a significant contribution to band-spreading. To account for the effect of coiling on axial dispersion, an empirical coefficient Θ is introduced in the expression for the effective axial dispersion coefficient, since a complete theory for this phenomenon does not exist. Attempts to correlate experimental Θ values with molecular weight of solutes, kinematic viscosity of carrier gases, film thickness, and temperature are described. A criterion is established for the improvement in resolution due to coiling.
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