Abstract
Optical coherence elastography (OCE) is one form of multi-channel imaging that combines high-resolution optical coherence tomography (OCT) imaging with mechanical tissue stimulation. This combination of structural and functional imaging can require additional space to integrate imaging capabilities with additional functional elements (e.g., optical, mechanical, or acoustic modulators) either at or near the imaging axis. We address this challenge by designing a novel scan lens based on a modified Schwarzchild objective lens, comprised of a pair of concentric mirrors with potential space to incorporate additional functional elements and minimal compromise to the available scan field. This scan objective design allows perpendicular tissue-excitation and response recording. The optimized scan lens design results in a working distance that is extended to ~140 mm (nearly 2x the focal length), an expanded central space suitable for additional functional elements (>15 mm in diameter) and diffraction-limited lateral resolution (19.33 μm) across a full annular scan field ~ ± 7.5 mm to ± 12.7 mm.
Highlights
A Multi-channel optical system contains several independent working channels with various functionalities, such as illumination, mechanical stimulation, imaging, etc
Optical coherence elastography (OCE) [4] is an emerging elasticity imaging technique that employs at least two channels
To simplify the calculation and keep the structure compact, we assigned d1 = (d1X + d1Y)/2 = d2 + 51.35 mm. This scan objective was designed for an optical coherence tomography (OCT) system with the capability of detecting 6.5 mm Optical path differences (OPDs) between the sample arm and the reference arm
Summary
A Multi-channel optical system contains several independent working channels with various functionalities, such as illumination, mechanical stimulation, imaging, etc. Dynamic elasticity imaging systems are used to determine tissue mechanical properties (e.g., stiffness) [2,3] by combining a mechanical loading channel (a source of sample stimulation) and an imaging channel to record the sample response. A loading channel is used to induce elastic waves in a tissue using techniques, such as optical, mechanical, or acoustic modulators for sample stimulation. The second channel uses optical coherence tomography (OCT) [16] imaging to record the tissue response. Compared to traditional ultrasound elastography [17,18,19] and magnetic resonance elastography [20,21], OCT can noninvasively obtain tissue mechanical properties with higher spatial resolution and faster speeds [22]. A targeting channel and a monitoring camera can be used for locating the regions of stimulus and imaging in the tissue
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