Abstract
Mie based theoretical analysis has been performed for investigation of the possibility of application of the plasma hemoglobin releasing due to local hemolysis for optical clearing of blood. The 30-40% reduction of the scattering coefficient of blood in the spectral range from 400 to 1000 nm with increase of degree of hemolysis (up to 20%) was shown. At the same time, the reduction of absorption coefficient of blood is localized mainly within the Soret band with maximum at 415 nm (---~15%), the alpha-band at 540 nm and the beta-band at 577 nm (~10%) of oxyhemoglobin. In the spectral range from 700 to 1000 nm the decrease of absorption coefficient is less than 8%.
Highlights
Myocardial infarction is the leading cause of death in the industrialized world
In the imaginary part of the relative refractive index of RBC the value of n′p is close to ne, χe is significantly greater than βCFHb
Mie based theoretical analysis has been performed to study the possibility of application of plasma hemoglobin releasing due to local hemolysis for optical clearing of blood
Summary
Myocardial infarction is the leading cause of death in the industrialized world. Most myocardial infarction results from the rupture of small, thin-walled plaques in the coronary arteries. The feasibility of index matching caused by a local hemolysis with production of some amount of free hemoglobin in the vicinity of optical head of endoscopic OCT or other endoscopy-spectroscopic system is demonstrated for the potential improvement of images of vessel wall lesions due to increase of light penetration through blood. Local increase of hemoglobin concentration, with refractive index greater than that of the plasma would decrease the difference in refractive indices between the scatterers (erythrocytes, leukocytes and thrombocytes) and their environment (blood plasma). Accompanied by decrease of scattering coefficient and increase of anisotropy factor of blood
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