Abstract
The theory of allosteric effects in equilibrium systems, as proposed previously, is extended to a time-dependent system. This system is represented by a pair of differential equations, one describing the binding of substrate with a protein, and the other describing the conformational change of an allosteric protein. The behaviour of solutions of these differential equations is investigated for two cases; one where the binding of substrate with protein controls the kinetics of the protein and another where the conformational change of protein controls the kinetics. The present theory accounts satisfactorily for the kinetics of oxygen with hemoglobin.
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