Theoretical studies and comparison with experiments on the horseradish peroxidase-oxidase reaction

Abstract

We study numerically the changes in the kinetics and the thermodynamics for the periodically forced oxidation of reduced nicotinamide adenine dinucleotide (NADH) by molecular oxygen. This reaction, which is catalyzed by the horseradish peroxidase enzyme, is referred to as the PO reaction. The model used for the calculations is the Degn-Olsen-Perram (DOP) model, a simple four-variable model. We choose different forms of external periodic perturbations in the inflow of molecular oxygen to observe the effect of such forms on the dissipation of the system