Theoretical justification of the choice of API in the composition of extemporal gel for treatment of wounds and bedsores

Abstract

Topicality. Treatment of chronic wounds and bedsores remains an urgent problem today, which requires the development of effective and safe drugs. Regardless of the cause, the pathogenesis of chronic wounds and bedsores is based on violations of trophic and protective properties of the skin, which develop due to tissue hypoxia.Aim. The aim of this work is theoretical research to substantiate the choice of active pharmaceutical ingredients (API) in the composition of extemporaneous gel for the treatment of chronic wounds and bedsores.Materials and methods. Methods of systematic and comparative analysis and bibliosemantic method of studying the modern view on the treatment of chronic wounds and the use of API for their treatment were used to search for information.Results and discussion. The article shows the relevance of the use of active pharmaceutical ingredients (decamethoxine and hyaluronic acid). Analysis of the literature showed that decamethoxine has a pronounced antibacterial, fungicidal and virocidal action, as well as has anti-inflammatory activity; hyaluronic acid - stimulates repair processes and accelerates epithelialization of wounds.Conclusions. The choice of API (decamethoxine and hyaluronic acid) in the composition of extemporaneous gel for the treatment of wounds and bedsores is theoretically substantiated.