Abstract
According to tue occupation theory of drug-receptor reactions the biological response is a function of the number of receptors occupied by drug molecules. It is generally assumed that the reaction is a bi-molecular one involving one molecule of drug and one molecule of receptor. In the present paper this assumption regarding the stoichiometry is generalized to n molecule; of drug reacting with m molecules of receptor. The method is derived for the determination of m and n and the consequences examined as related to the major theories of receptor occupation theory. It is shown that the value of m significancy alters the estimation of both the affinity constant of the drug-receptor complex and the number of ‘spare’ receptors. The significance of independent and dependent effects is also discussed.
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