Abstract
The neodymium(III) complex of orotic acid (HOA) was synthesized and its structure determined by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA, and Nd(III)–OA systems based on both the calculated and experimental spectra confirmed the suggested metal–ligand binding mode. Significant differences in the IR and Raman spectra of the complex were observed as compared to the spectra of the ligand. The calculated vibrational wavenumbers, including IR intensities and Raman scattering activities, for the ligand and its Nd(III) complex were in good agreement with the experimental data. The vibrational analysis performed for the studied species, orotic acid, sodium salt of orotic acid, and its Nd(III) complex helped to explain the vibrational behaviour of the ligand’s vibrational modes, sensitive to interaction with Nd(III). In this paper we also report preliminary results about the cytotoxicity of the investigated compounds. The cytotoxic effects of the ligand and its Nd(III) complex were determined using the MTT method on different tumour cell lines. The screening performed revealed that the tested compounds exerted cytotoxic activity upon the evaluated cell lines.
Highlights
Lanthanide complexes are of great interest because of their various potential applications
IR and Raman spectra confirmed the nature of the complex
The obtained elemental analysis data of the new neodymium(III) complex served as the basis for the determination of its empirical formula, and the results of the Karl Fischer titration are presented below
Summary
Lanthanide complexes are of great interest because of their various potential applications. Due to the unique nature of lanthanide ions, such as their large radius and high coordination number, the assembly of lanthanide complexes possessing novel structures and special properties offers great challenges and opportunities in terms of controlling their shapes and dimensions. The selection of an appropriate organic ligand along with different synthetic methods is a key step in the construction of lanthanide complexes with the desired features. Ligands containing a combination of nitrogen and oxygen donor atoms demonstrate flexible coordination modes during the formation of coordination frameworks, which is why the studied lanthanide(III) complexes of biologically active derivatives of orotic acid deserve to be examined. Metal orotates are widely applied in medicine [6], with platinum, palladium, and nickel orotate complexes being screened as potential therapeutic agents for cancer [7] The coordination chemistry of orotic acid (2,6-dioxo-1,2,3,6-tetrahydropyrimidine4-carboxylic acid, vitamin B13 , or HOA) and its sodium salt (NaOA) (see Figure 1) has been an area of great interest [1,2,3,4,5], ranging from bioinorganic to pharmaceutical and materials chemistry.
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