Abstract

In this article, a description has been given of theoretical and experimental investigations of the factors beyond frontier molecular orbital interactions which are important in influencing mechanisms, rates, and regioselectivities of cycloadditions and related reactions of unsaturated systems. Closed-shell repulsion, geometrical distortions, polarization, and secondary orbital interactions have all been shown to be influential. Electrostatic interactions and correlation effects have not been discussed, but will provide further refinements — or confusion, depending upon the reader's point of view! As Professor Huisgen recently commented, there are now a distressingly large number of “buttons to push”, to explain various phenomena91). This is, indeed, the case at the present time, primarily due to our limited knowledge about the magnitudes of these many effects. The cases discussed here constitute examples where the cited effects seem to prevail over others, but similar effects will be present to some extent in all reactions. Our current research efforts constitute attempts to understand more generally when these effects are significant, and to be able to understand and predict rates and products of organic reactions.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.