Abstract
Toxicokinetics, the application of pharmacokinetic principles in the assessment and management of the poisoned patient, is demonstrated for theophylline poisonings. Theophylline intoxication and its treatment is briefly reviewed and differentiated for acute or chronic etiologies. A toxicokinetic strategy for the simple calculation and evaluation of serum theophylline concentrations following sustained-release products overdosage is presented. A toxicokinetic basis for treatment durations of activated charcoal, hemoperfusion, or hemodialysis is described. Common toxicokinetic factors responsible for presentation with chronic theophylline intoxication are mentioned.
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