Abstract
In this issue of Pediatrics, Ellis et al.1 have a study of the pharmocokinetics of theophylline, a study which is 40 years overdue and which was technically feasible 25 years ago. They show that children are not "little adults" in that the dosage of theophylline and the dosing intervals in children cannot be based on adult studies. Their work shows that theophylline has a significantly shorter biologic half-life in children, and that intersubject variation is far greater, with a range of 1.4 to 7.8 hours. Thus, compared to adults, children tend to require relatively larger amounts of theophylline per kilogram of body weight per day, and the doses may have to be given at shorter intervals of time.
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