Abstract
A 10-kb DNA fragment containing thegndgene fromActinobacillus actinomy-cetemcomitansY4 was isolated and sequenced. The structuralgndgene codes for 6-phosphogluconate dehydrogenase that consists of 484 amino acids. In contrast to thegndgene inEscherichia coli, Salmonella typhimurium,orKlebsiella pneumoniae,thegndgene ofA. actinomycetemcomitanswas not located in therfborcpsoperon. Thezwfgene encoding glucose 6-phosphate dehydrogenase, which is another enzyme consisting of pentose-phosphate pathway, sided at 3.8-kb upstream from thegndgene. A phylogenetic tree based on sequence analyses showed higher homology of 6-phospho-gluconate dehydrogenase ofA. actinomycetemcomitanswith the eucaryotic enzymes rather than with bacterial enzymes.
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