Abstract
A 10-kb DNA fragment containing thegndgene fromActinobacillus actinomy-cetemcomitansY4 was isolated and sequenced. The structuralgndgene codes for 6-phosphogluconate dehydrogenase that consists of 484 amino acids. In contrast to thegndgene inEscherichia coli, Salmonella typhimurium,orKlebsiella pneumoniae,thegndgene ofA. actinomycetemcomitanswas not located in therfborcpsoperon. Thezwfgene encoding glucose 6-phosphate dehydrogenase, which is another enzyme consisting of pentose-phosphate pathway, sided at 3.8-kb upstream from thegndgene. A phylogenetic tree based on sequence analyses showed higher homology of 6-phospho-gluconate dehydrogenase ofA. actinomycetemcomitanswith the eucaryotic enzymes rather than with bacterial enzymes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.