Abstract
Theabrownin (TB) is a complex oxidized polyphenol formed during the microbial fermentation of Pu-erh tea. It offers some health benefits such as weight loss, blood glucose reduction, and oxidation resistance; however, the anti-aging effect and the related mechanism have not yet been explored. In this study, symptoms of aging were induced in mice using D-galactose. Morris water maze test, hematoxylin-eosin staining, 16S rDNA high-throughput sequencing, and UHPLC-QE-MS metabolomics were used to reveal the anti-aging effects and potential mechanism of TB. TB improved the learning and memory ability, the liver oxidative stress (SOD, GSH-Px, and MDA), inflammation (IL-2, IL-6, and TNF-α), and degeneration of the small intestine in the aging mice. Further analysis showed that TB pretreatment increased the relative abundance of Lactobacillus_murinus and Bacteroides_acidifaciens, and regulated 19 metabolites in the serum. In addition, TB treatment increased the relative abundance of Akkermansia_muciniphila, and regulated 12 metabolites. In conclusion, the anti-aging effect of TB is exerted by the targeted regulation of intestinal microorganisms, which could prevent and delay aging.
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