Abstract
Using electrophoresis in antibody-containing agarose gel with planimetric evaluation of antigen—antibody precipitation peak area, Zn-α 2 -glycoprotein was quantitatively estimated in normal human serum at different ages. Quantitative differences were found between the main Zn-α 2 -glycoprotein concentration in fetal serum (2.5 ± 1.8 mg/100 ml), cord serum (4.8 ± 1.6 mg/100 ml) and serum of infants, children, adolescents and adults (8.9 ± 2.2 mg/100 ml 10.4 ± 4.0 mg/100 ml). The Zn-α 2 -glycoprotein concentration in serum increases already during the first few days after birth as compared with its concentration in cord serum, to reach the mean values representative for postnatal age approximately between the first and second week after birth. Differences from normal human serum Zn-α 2 -glycoprotein concentration during ontogenesis may be expected in pathological conditions. At present this phenomenon is being studied in detail, especially in nephropathies and autoimmune diseases.
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