Abstract
Introduction: Evidence from animal studies suggests that Zingiber officinale (ginger) may help prevent ischemia–reperfusion injury (IRI) in heart. The aim of the present study was to investigate the effect of ginger on inducing preconditioning on patients undergoing angioplasty. Methods: Thirty-four patients, referred for elective angioplasty, were randomly divided into the control (17 patients) and ginger groups (17 patients). Subjects in the experimental group were provided 250 mg ginger powder in Zintoma capsules per day for 10 days, whereas those in the control group received placebo. The patients underwent percutaneous transluminal coronary angioplasty (PTCA) (One 45-second balloon inflation and 2 minutes reperfusion). Chest pain scores were assessed immediately after angioplasty and cardiac injury biomarkers were assessed 12 hours later. Results: The average pain score during the balloon inflation in the ginger group was significantly lower than the control group (2.1±1 versus 3.8±1.5, P = 0.04). Troponin I was elevated in both groups after angioplasty, but there was not any significant difference between groups in this regard (P = 0.12 and 0.10, respectively). Conclusion: The use of ginger reduces chest pain during coronary angioplasty but its effect on the release of biochemical markers of myocardial damage is obscure.
Highlights
Evidence from animal studies suggests that Zingiber officinale may help prevent ischemia–reperfusion injury (IRI) in heart
The results of the present study showed that usage of 250 mg ginger during 10 days before percutaneous transluminal coronary angioplasty (PTCA) reduces chest pain but has no effect on release of cardiac biomarkers
Based on the anti-inflammatory effect of ginger this hypothesis was extracted that ginger might be used in reducing IRI
Summary
Evidence from animal studies suggests that Zingiber officinale (ginger) may help prevent ischemia–reperfusion injury (IRI) in heart. Results: The average pain score during the balloon inflation in the ginger group was significantly lower than the control group (2.1±1 versus 3.8±1.5, P = 0.04). Conclusion: The use of ginger reduces chest pain during coronary angioplasty but its effect on the release of biochemical markers of myocardial damage is obscure. Ischemia–reperfusion injury (IRI) occurs after the treatment of myocardial infarction and other elective procedures such as open heart surgery and coronary angioplasty [1]. The most important theory to reduce IRI is ischemic preconditioning (IPC) introduced by Murry et al who suggested that the short episodes of ischemiareperfusion increase myocardial tolerance to long periods of severe ischemia and reperfusion after cardiac events [2].
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