Abstract
The 1st International Workshop on Xenotropic Murine Leukemia Virus-Related Retrovirus (XMRV), co-sponsored by the National Institutes of Health, The Department of Health and Human Services and Abbott Diagnostics, was convened on September 7/8, 2010 on the NIH campus, Bethesda, MD. Attracting an international audience of over 200 participants, the 2-day event combined a series of plenary talks with updates on different aspects of XMRV research, addressing basic gammaretrovirus biology, host response, association of XMRV with chronic fatigue syndrome and prostate cancer, assay development and epidemiology. The current status of XMRV research, concerns among the scientific community and suggestions for future actions are summarized in this meeting report.
Highlights
In 2006, Urisman et al [1] described the identification and characterization of a novel gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in a small number of prostate cancers
In cautioning that expansion of the model is urgently needed, this study provided a valuable model of human XMRV infection to assess long-term chronic infection, pathogenesis, immunity and for validating potential vaccines
Using nested PCR, MLV-like gag gene sequences could be amplified from peripheral blood mononuclear cells (PBMCs) DNA in 32 of 37 patients meeting the accepted diagnostic criteria for chronic fatigue syndrome (CFS) (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors
Summary
In 2006, Urisman et al [1] described the identification and characterization of a novel gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in a small number of prostate cancers. An assay with such sensitivity, possibly complementing one directed against mouse mitochondrial DNA, would guard against contaminating DNA in future PCR studies designed to detect XMRV and related viruses in human samples.
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