Abstract
Summary It is shown that the capacity for rapid and augmented recall of cellular IgM antibody production (“IgM memory”), in the sheep red cell system of the mouse, can be detected as early as 1 day after an initial dose of 2 × 106 SRBC, and reaches a peak concomitant with the peak of the IgM response. The transitory nature of this capacity is indicated, firstly, by its eight-fold decrease 1 month after priming. Secondly, if the net excess secondary response is induced 1 day or 1 month following priming, rather than at the optimal time, the “memory” increment falls to zero quickly. These findings have given rise to an altered view of the heterogeneity of the Y or memory cell which is discussed at length.
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