Abstract
Absorption, distribution, and excretion of 3H-pregnanediol after its percutaneous or intraperitoneal administration in female mice and rats were studied by autoradiography and liquid scintillation counting. Examination of absorption showed that 14% of the percutaneously administered radioactivity was absorbed during 48 hours. Microautoradiograms of rat skin applied with 3H-pregnanediol ointment suggested that the drug was absorbed through stratum malpighi of the cuticle and hair-follicles. Thirty minutes after intraperitoneal injection of 3H-pregnanediol in female mice, high concentration of the radioactivity was found in the gall bladder and intestinal content. A moderate level of the radioactivity was observed in the liver. Levels of radioactivity in other tissues were as low as that in blood. The lowest concentration was found in the brain. Twenty-four hours after intraperitoneal administration radioactivity in various organs except in intestinal contents decreased markedly.
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