Abstract
The white pock (μ) host range (hr) mutants of rabbit poxvirus (RPμhr mutants) can be divided into two subclasses (early and late) based on their ability to synthesize viral DNA in nonpermissive pig kidney (PK) cells. We have previously shown that the infection of PK cells by two early (DNA minus) mutants is abortive due to an inhibition of translation early in the infectious cycle. Here we have examined the abortive infection of PK cells by three late (DNA plus) mutants. All three late mutants synthesize DNA and late proteins (at reduced levels) in PK cells but each of the three late mutants is missing a late viral protein of 72,000 daltons. The three late mutants appear to process the precursor structural proteins in a normal fashion suggesting that viral morphogenesis begins. No induction of particulate viral RNA polymerase indicative of internal core differentiation is observed, however, and little, if any, mature virus is formed. Instead, infection of nonpermissive cells leads to the accumulation of DNA-containing, primitive immature principles (PIPS) which do not differentiate further into virus.
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