The wettability of electron spun membranes by synovial fluid.

Ales Hrouda,Lukas Capek,Kathleen Denis,Maarten Vanierschot,Radek Jirkovec,Petra Hamrikova

doi:10.1098/rsos.210892

Ales Hrouda, Lukas Capek + Show 4 more

Open Access

https://doi.org/10.1098/rsos.210892

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Abstract

Aseptic loosening due to periprosthetic osteolysis has been accepted as one of the leading causes of revision procedures in patients with previous joint arthroplasty. Recently, several strategies for suppression of osteolysis were proposed, mostly based on biological treatment such as mitigation of chronic inflammatory reactions. However, these biological treatments do not stop the debris migration but only reduce the inflammatory reaction. To address this shortcoming, we propose the concept of ultrahigh molecular weighted polyethylene particles filtration storage by electrospun membranes. Firstly, the surface tension of synovial fluid (SF) is obtained by use of a pendant droplet. Secondly, the contact angle of the electrospun membranes wetted by two different liquids is measured to obtain the free surface energy using of the Owens–Wendt model. Additionally, the wettability of electrospun membranes by SF as a function of technology parameters is studied.

Highlights

Electrospun materials have shown a large scale of biomedical applications in the last decade and still draw increasing attention in this field [1,2,3,4]
We have focused on a concept of a new implant using an electrospun membrane for the prevention of ultrahigh molecular weighted polyethylene (UHMWPE) wear-induced osteolysis
We have focused on a concept of a new implant using an electrospun membrane for the prevention of UHMWPE wearinduced osteolysis

Summary

Introduction

Electrospun materials have shown a large scale of biomedical applications in the last decade and still draw increasing attention in this field [1,2,3,4]. Among the outstanding benefits of such materials, the following must be mentioned: high biocompatibility, tunable solubility, size and structural variability, straightforward chemical functionalization and, on a large scale, productivity. In regard of functionalization and filtration properties, the wettability of the interface between biological liquid and the membrane must be known [5,6]. This information determines whether the membrane is hydrophilic or hydrophobic in nature and aids in determining the royalsocietypublishing.org/journal/rsos R. Understanding the exact wettability characteristics will greatly assist with any membrane future applications

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